Blood Transfusion Research Today is a free monthly online journal that collates and summarizes the latest research about Blood Transfusion, including details on blood donation, blood types, leukemia.

Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature.

Church GD, Price C, Sanchez R, Looney MR

Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0130, USA. gwynnechurch@yahoo.com

Transfusion-related acute lung injury (TRALI) is increasingly recognized as a major complication of transfusion therapy; it was the leading cause of transfusion-related fatalities in the United States in 2003. Most cases of TRALI that have been reported are in adult patients. We present two cases of TRALI that occurred in children and review the existing literature of paediatric TRALI. The paediatric TRALI case reports highlight two laboratory findings that can help in the diagnosis of TRALI: transient leucopenia and an elevated pulmonary oedema fluid/plasma protein ratio. These two simple diagnostic tests can help rule out other diagnoses and add confidence to the clinical diagnosis of TRALI. Finally, our first case also highlights the potential danger of directed maternal blood donations, which may increase the risk of paediatric TRALI.

Published 26 September 2006 in Transfus Med, 16(5): 343-8.
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